My research focuses on the ability of a DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT, also called MGMT), to repair alkylguanine and alkylthymine adducts in various DNA structures. In particular, my research focuses on G-quadruplex DNA structures. I am interested in examining the efficacy of AGT to repair alkylations in other DNA structures like I-motifs, hairpins, bulges, etc. AGT is a protein that is overexpressed in malignant glioblastoma multiforme tumors of the brain. I have a number of publications that include Nature Protocols, Nucleic Acids Research, and Molecular Therapy.
I received my PhD from the University of Kentucky in Biochemistry. I then went to the University of Notre Dame for a postdoctoral position. I left Notre Dame as a Research Assistant Professor to join the Nevada State College family. I spend my off time with my family, preferably hiking whenever we can.
Dr. Hellman regularly teaches: Chem 108 (Intro to Chemistry), Chem 212 (Intro to Chemical Pharmacology and Toxicology), BIOL 350 (Medical Epidemiology), and BIOL 405 (Molecular Biology)
For more information about Dr. Hellman please click: CV_Hellman_2019
Office: Liberal Arts and Sciences (LAS) 257
Phone: (702) 992-2733